Innovative Research in T cell Biology and Cancer Immunology

T cells are key effector cells in anti-tumor immunity.  We study the molecular mechanisms that control T cell function in the tumor microenvironment, with a particular focus on inhibitory pathways that constrain T cell effector function.  We also study the mechanisms that allow tumor cells to evade T cell-mediated attack.  Our approach integrates mechanistic studies in experimental models with interrogation of discovered pathways in humans in order to translate our discoveries to clinical application.  

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