Innovative Research in T cell Biology and Cancer Immunology
T cells are key players in the immune system with the ability to detect and eliminate infected or transformed cells. We study the molecular mechanisms controlling antigen presentation to T cells, antigen recognition by the T cell receptor as well as activating and inhibitory signaling. We are particularly interested in T cell responses to self-antigens, which is beneficial in anti-tumor immunity yet detrimental in autoimmune diseases. Our projects aim to provide definitive mechanistic insights to key questions in the field. We use advanced tools to address these questions, ranging from in vivo studies to biochemistry, imaging and structural biology.